Contact Information

Semel Institute for Neuroscience and Human Behavior
760 Westwood Plaza
C8-881
Mail Code 175919
Los Angeles, CA 90095
Tel: (310) 794-6386
Fax: (310) 794-7406
E-mail: sbook@ucla.edu

I have been a member of the UCLA faculty since 1993. My research uses functional Magnetic Resonance Imaging (FMRI) to understand the cortical organization of language and memory systems including emergent systems such as social communication and emotion. Clinical applications of my work includes pre-surgical mapping of critical functions; understanding developmental disorders of language such as autism and ADHD; and early detection of functional brain abnormalities in individuals at-risk for Alzheimer's disease.

Selected References

Small, G.W., L.M. Ercoli, D.H.S. Silverman, S.C. Huang, S.Y. Bookheimer, H. Lavretsky, K. Miller, P. Siddar, J. Mazziota, A.M. Saunders, M.A. Pericak-Vance, A.D. Roses, J.R. Barrio and M.E. Phelps Influence of apoE Genotype and PET Brain Imaging on Preclinical Prediction of Alzeimer's Diesease.. Alzheimer's Disease: Advances in Etiology, Pathogenisis and Therapeutics 2001; 18: 193-203.

Hairiri, A., S.Y. Bookheimer, and J. Mazziota A Neural Network for Modulating the Emotional Response to Faces.. Neuroreport 2000; 11(1): 43-48.

Bookheimer, S.Y. and M. Sigman Eploring the Neural Basis of Social Communication Disorders.. NeuroReport 2000; 11(13): F13.

Bookheimer, SY Methodological issues in pediatric neuroimaging.. Mental retardation and developmental disabilities research reviews. . 2000; 6(3): 161-5.

Davidson, RJ Bookheimer, SY Pediatric neuroimaging and developmental disorders of cognition and affect: introduction to the special issue. Ment. Retard Dev. Disabil. Res. Rev.. 2000; 6(3): 159-60.

Cannestra, A.F., S.Y. Bookheimer, N. Pouratian, A. O'Farrell, N. Sicotte, N.A. Martin, D.P. Beckerand, G. Rubino and A.W. Toga Temporal and Topographical Characteristization of Language Cortices Using Intraoperative Optical Intrinsic Signals.. NeuroImage 2000; 12(1): 41-54.

Gaillard, W.D., S.Y. Bookheimer and M.S. Cohen The Use of fMRI in Neocortical Epilepsy.. Advanced Neurology 2000; 84: 391-404.

Bookheimer, S.Y., M. Dapretto and U. Karmarhar Functional MRI in Children with Epilepsy.. Developmental Neurosciences 1999; 21(3-5): 191-199.

Gaillard, W.D., S.Y. Bookheimer, L. Hertz-Pannier, and T.A. Blaxton The Non-Invasive Identification of Language Function: Neuroimaging and Rapid Transcranial Magnetic Stimulation.. Neurosurgical Clin. North America 1999; 8(3): 321-335.

Hunter, K.E., T. A. Blaxton, S.Y. Bookheimer, C. Figlozzi, C. Grandin, A. Anyanwu and W.H. Theodore O Water Positron Emission Tomography in Language Localization: A Study Comparing Rater Evaluations and Computerized Region of Interest Analysis of PET Studies with the WADA Test.. Annals of Neurology 1998; 45(5): 662-665.

Bookheimer, S.Y., T.A. Zeffiro, T. Blaxton , W.D. Gaillard, B. Mallow, W.H. Theodore Regional Central Blood Flow During Auditory Response Naming: Evidence for Cros-Modality Neural Activation.. Neuroreport 1998; 9(10): .

Cohen, M.S., S.M. Kosslyn, H.C. Breiter, G.J. DiGirolamo, W.L. Thompson, S.Y. Bookheimer, J.W. Belliveau and B.R. Rosen Changes in Cortical Activity During Mental Rotation: A Mapping Study Using Functional Magnetic Resonsance Imaging.. Brain 1996; 119: 89-100.
Bookheimer, S.Y. Functional MRI Applications in Clinical Epilepsy.. NeuroImage 1996; 4(3): S139-S146.

Blaxton, T.A., S.Y. Bookheimer, T.A. Zeffiro, C.M. Figlozzi, W. Gaillard and W. Theodore Functional Mapping of Human Memory Using PET: Comparisons of Conceptual and Perceptual Tasks.. Canadian Journal of Experimental Psychology 1996; 50(1): 42-56.

Bookheimer, S.Y., T.A. Zeffiro, T. Blaxton, W.D. Gaillard and W.H. Theodore Regional Cerebral Blood Flow During Object Naming and Word Reading.. Human Brain Mapping 1995; 3(2): 93-106.

Cohen, M.S. and S.Y. Bookheimer Functional Magnetic Resonance Imaging.. Trends in Neurosciences 1994; 17(7): 268-277.

O'Hare Elizabeth D, Lu Lisa H, Houston Suzanne M, Bookheimer Susan Y, Sowell Elizabeth R Neurodevelopmental changes in verbal working memory load-dependency: An fMRI investigation.. NeuroImage. 2008; 42(4): 1678-85.

Ekstrom Arne, Suthana Nanthia, Behnke Eric, Salamon Noriko, Bookheimer Susan, Fried Itzhak High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy.. Journal of neurosurgery. 2008; 108(4): 812-5.

Small Gary W, Bookheimer Susan Y, Thompson Paul M, Cole Greg M, Huang S-C, Kepe Vladimir, Barrio Jorge R Current and future uses of neuroimaging for cognitively impaired patients.. Lancet neurology. 2008; 7(2): 161-72.

Sowell Elizabeth R, Johnson Arianne, Kan Eric, Lu Lisa H, Van Horn John Darrell, Toga Arthur W, O'Connor Mary J, Bookheimer Susan Y Mapping white matter integrity and neurobehavioral correlates in children with fetal alcohol spectrum disorders.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008; 28(6): 1313-9.

Foland Lara C, Altshuler Lori L, Bookheimer Susan Y, Eisenberger Naomi, Townsend Jennifer, Thompson Paul M Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania.. Psychiatry research. 2008; 162(1): 27-37.

Belmonte Matthew K, Mazziotta John C, Minshew Nancy J, Evans Alan C, Courchesne Eric, Dager Stephen R, Bookheimer Susan Y, Aylward Elizabeth H, Amaral David G, Cantor Rita M, Chugani Diane C, Dale Anders M, Davatzikos Christos, Gerig Guido, Herbert Martha R, Lainhart Janet E, Murphy Declan G, Piven Joseph, Reiss Allan L, Schultz Robert T, Zeffiro Thomas A, Levi-Pearl Susan, Lajonchere Clara, Colamarino Sophia A Offering to share: how to put heads together in autism neuroimaging.. Journal of autism and developmental disorders. 2008; 38(1): 2-13.

Foerde Karin, Poldrack Russell A, Khan Barbara J, Sabb Fred W, Bookheimer Susan Y, Bilder Robert M, Guthrie Don, Granholm Eric, Nuechterlein Keith H, Marder Stephen R, Asarnow Robert F Selective corticostriatal dysfunction in schizophrenia: examination of motor and cognitive skill learning.. Neuropsychology. 2008; 22(1): 100-9.

de Bode Stella, Mathern Gary W, Bookheimer Susan, Dobkin Bruce Locomotor training remodels fMRI sensorimotor cortical activations in children after cerebral hemispherectomy.. Neurorehabilitation and neural repair. 2007; 21(6): 497-508.

Feusner Jamie D, Townsend Jennifer, Bystritsky Alexander, Bookheimer Susan Visual information processing of faces in body dysmorphic disorder.. Archives of general psychiatry. 2007; 64(12): 1417-25.

Hale T Sigi, Bookheimer Susan, McGough James J, Phillips Joseph M, McCracken James T Atypical brain activation during simple & complex levels of processing in adult ADHD: an fMRI study.. Journal of attention disorders. 2007; 11(2): 125-40.

Sabb Fred W, Bilder Robert M, Chou Maggie, Bookheimer Susan Y Working memory effects on semantic processing: priming differences in pars orbitalis.. NeuroImage. 2007; 37(1): 311-22.

Bookheimer Susan Pre-surgical language mapping with functional magnetic resonance imaging.. Neuropsychology review. 2007; 17(2): 145-55.

Sowell Elizabeth R, Lu Lisa H, O'Hare Elizabeth D, McCourt Sarah T, Mattson Sarah N, O'Connor Mary J, Bookheimer Susan Y Functional magnetic resonance imaging of verbal learning in children with heavy prenatal alcohol exposure.. Neuroreport. 2007; 18(7): 635-9.

Cook Ian A, Bookheimer Susan Y, Mickes Laura, Leuchter Andrew F, Kumar Anand Aging and brain activation with working memory tasks: an fMRI study of connectivity.. International journal of geriatric psychiatry. 2007; 22(4): 332-42.

Ekstrom Arne, Viskontas Indre, Kahana Michael, Jacobs Josh, Upchurch Kristen, Bookheimer Susan, Fried Itzhak Contrasting roles of neural firing rate and local field potentials in human memory.. Hippocampus. 2007; 17(8): 606-17.

Small Gary W, Kepe Vladimir, Ercoli Linda M, Siddarth Prabha, Bookheimer Susan Y, Miller Karen J, Lavretsky Helen, Burggren Alison C, Cole Greg M, Vinters Harry V, Thompson Paul M, Huang S-C, Satyamurthy N, Phelps Michael E, Barrio Jorge R PET of brain amyloid and tau in mild cognitive impairment.. The New England journal of medicine. 2006; 355(25): 2652-63.

Small Gary W, Silverman Daniel H S, Siddarth Prabha, Ercoli Linda M, Miller Karen J, Lavretsky Helen, Wright Benjamin C, Bookheimer Susan Y, Barrio Jorge R, Phelps Michael E Effects of a 14-day healthy longevity lifestyle program on cognition and brain function.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2006; 14(6): 538-45.

Ercoli Linda, Siddarth Prabha, Huang Sung-Cheng, Miller Karen, Bookheimer Susan Y, Wright Benjamin C, Phelps Michael E, Small Gary Perceived loss of memory ability and cerebral metabolic decline in persons with the apolipoprotein E-IV genetic risk for Alzheimer disease.. Archives of general psychiatry. 2006; 63(4): 442-8.

Dapretto Mirella, Davies Mari S, Pfeifer Jennifer H, Scott Ashley A, Sigman Marian, Bookheimer Susan Y, Iacoboni Marco Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disorders.. Nature neuroscience. 2006; 9(1): 28-30.

Altshuler Lori L, Bookheimer Susan Y, Townsend Jennifer, Proenza Manuel A, Eisenberger Naomi, Sabb Fred, Mintz Jim, Cohen Mark S Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study.. Biological psychiatry. 2005; 58(10): 763-9.

Lieberman Matthew D, Hariri Ahmad, Jarcho Johanna M, Eisenberger Naomi I, Bookheimer Susan Y An fMRI investigation of race-related amygdala activity in African-American and Caucasian-American individuals.. Nature neuroscience. 2005; 8(6): 720-2.

Altshuler Lori, Bookheimer Susan, Proenza Manuel A, Townsend Jennifer, Sabb Fred, Firestine Ann, Bartzokis George, Mintz Jim, Mazziotta John, Cohen Mark S Increased amygdala activation during mania: a functional magnetic resonance imaging study.. The American journal of psychiatry. 2005; 162(6): 1211-3.

Poldrack Russell A, Sabb Fred W, Foerde Karin, Tom Sabrina M, Asarnow Robert F, Bookheimer Susan Y, Knowlton Barbara J The neural correlates of motor skill automaticity.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(22): 5356-64.

Eldridge Laura L, Engel Stephen A, Zeineh Michael M, Bookheimer Susan Y, Knowlton Barbara J A dissociation of encoding and retrieval processes in the human hippocampus.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(13): 3280-6.

Bookheimer Susan, Schrader Lara M, Rausch Rebecca, Sankar Raman, Engel Jerome Reduced anesthetization during the intracarotid amobarbital (Wada) test in patients taking carbonic anhydrase-inhibiting medications.. Epilepsia. 2005; 46(2): 236-43.

Cannestra Andrew F, Pouratian Nader, Forage James, Bookheimer Susan Y, Martin Neil A, Toga Arthur W Functional magnetic resonance imaging and optical imaging for dominant-hemisphere perisylvian arteriovenous malformations.. Neurosurgery. 2004; 55(4): 804-12; discussion 812-4.

Pouratian Nader, Cannestra Andrew F, Bookheimer Susan Y, Martin Neil A, Toga Arthur W Variability of intraoperative electrocortical stimulation mapping parameters across and within individuals.. Journal of neurosurgery. 2004; 101(3): 458-66.

Lieberman Matthew D, Chang Grace Y, Chiao Joan, Bookheimer Susan Y, Knowlton Barbara J An event-related fMRI study of artificial grammar learning in a balanced chunk strength design.. Journal of cognitive neuroscience. 2004; 16(3): 427-38.

Moody Teena D, Bookheimer Susan Y, Vanek Zeba, Knowlton Barbara J An implicit learning task activates medial temporal lobe in patients with Parkinson's disease.. Behavioral neuroscience. 2004; 118(2): 438-42.

Lavretsky Helen, Ercoli Linda, Siddarth Prabha, Bookheimer Susan, Miller Karen, Small Gary Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2004; 11(6): 667-73.

Piggot Judith, Kwon Hower, Mobbs Dean, Blasey Christine, Lotspeich Linda, Menon Vinod, Bookheimer Susan, Reiss Allan L Emotional attribution in high-functioning individuals with autistic spectrum disorder: a functional imaging study.. Journal of the American Academy of Child and Adolescent Psychiatry. 2004; 43(4): 473-80.

Wang A Ting, Dapretto Mirella, Hariri Ahmad R, Sigman Marian, Bookheimer Susan Y Neural correlates of facial affect processing in children and adolescents with autism spectrum disorder.. Journal of the American Academy of Child and Adolescent Psychiatry. 2004; 43(4): 481-90.

Hernandez Arturo E, Kotz Sonja A, Hofmann Juliane, Valentin Vivian V, Dapretto Mirella, Bookheimer Susan Y The neural correlates of grammatical gender decisions in Spanish.. Neuroreport. 2004; 15(5): 863-6.

Pouratian Nader, Sheth Sameer, Bookheimer Susan Y, Martin Neil A, Toga Arthur W Applications and limitations of perfusion-dependent functional brain mapping for neurosurgical guidance.. Neurosurgical focus. 2003; 15(1): E2.

Pouratian Nader, Bookheimer Susan Y, Rubino Gregory, Martin Neil A, Toga Arthur W Category-specific naming deficit identified by intraoperative stimulation mapping and postoperative neuropsychological testing. Case report.. Journal of neurosurgery. 2003; 99(1): 170-6.

Gelfand Jenna R, Bookheimer Susan Y Dissociating neural mechanisms of temporal sequencing and processing phonemes.. Neuron. 2003; 38(5): 831-42.

Zeineh Michael M, Engel Stephen A, Thompson Paul M, Bookheimer Susan Y Dynamics of the hippocampus during encoding and retrieval of face-name pairs.. Science (New York, N.Y.). 2003; 299(5606): 577-80.

Pouratian Nader, Bookheimer Susan Y, Rex David E, Martin Neil A, Toga Arthur W Utility of preoperative functional magnetic resonance imaging for identifying language cortices in patients with vascular malformations.. Neurosurgical focus. 2002; 13(4): e4.

Pouratian Nader, Bookheimer Susan Y, Rex David E, Martin Neil A, Toga Arthur W Utility of preoperative functional magnetic resonance imaging for identifying language cortices in patients with vascular malformations.. Journal of neurosurgery. 2002; 97(1): 21-32.

Mega Michael S, Small Gary W, Xu Mina L, Felix Jenaro, Manese Mario, Tran Nha P, Dailey Jason I, Ercoli Linda M, Bookheimer Susan Y, Toga Arthur W Hippocampal atrophy in persons with age-associated memory impairment: volumetry within a common space.. Psychosomatic medicine. 2002; 64(3): 487-92.

Kroger James K, Sabb Fred W, Fales Christina L, Bookheimer Susan Y, Cohen Mark S, Holyoak Keith J Recruitment of anterior dorsolateral prefrontal cortex in human reasoning: a parametric study of relational complexity.. Cerebral cortex (New York, N.Y. : 1991). 2002; 12(5): 477-85.

Kroger, JK Sabb, FW Fales, CL Bookheimer, SY Cohen, MS Holyoak, KJ Recruitment of anterior dorsolateral prefrontal cortex in human reasoning: a parametric study of relational complexity.. Cerebral cortex (New York, N.Y. : 1991) . 2002; 12(5): 477-85.

Bookheimer Susan Functional MRI of language: new approaches to understanding the cortical organization of semantic processing.. Annual review of neuroscience. 2002; 25(1): 151-88.

Burggren Alison C, Small Gary W, Sabb Fred W, Bookheimer Susan Y Specificity of brain activation patterns in people at genetic risk for Alzheimer disease.. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2002; 10(1): 44-51.

Burggren Alison C, Bookheimer Susan Y Structural and functional neuroimaging in Alzheimer's disease: an update.. Current topics in medicinal chemistry. 2002; 2(4): 385-93.

Hernandez, AE Dapretto, M Mazziotta, J Bookheimer, S Language switching and language representation in Spanish-English bilinguals: an fMRI study.. NeuroImage. . 2001; 14(2): 510-20.

Cannestra, AF Pouratian, N Bookheimer, SY Martin, NA Beckerand, DP Toga, AW Temporal spatial differences observed by functional MRI and human intraoperative optical imaging.. Cerebral cortex (New York, N.Y. : 1991) . 2001; 11(8): 773-82.

Rasgon, NL Small, GW Siddarth, P Miller, K Ercoli, LM Bookheimer, SY Lavretsky, H Huang, SC Barrio, JR Phelps, ME Estrogen use and brain metabolic change in older adults. A preliminary report.. Psychiatry research. . 2001; 107(1): 11-8.

Zeineh, MM Engel, SA Thompson, PM Bookheimer, SY Unfolding the human hippocampus with high resolution structural and functional MRI.. The Anatomical record. . 2001; 265(2): 111-20.

Eldridge, LL Knowlton, BJ Furmanski, CS Bookheimer, SY Engel, SA Remembering episodes: a selective role for the hippocampus during retrieval.. Nature neuroscience. . 2000; 3(11): 1149-52.

Bookheimer, SY Zeffiro, TA Blaxton, TA Gaillard, PW Theodore, WH Activation of language cortex with automatic speech tasks.. Neurology. . 2000; 55(8): 1151-7.

Pouratian, N Bookheimer, SY O'Farrell, AM Sicotte, NL Cannestra, AF Becker, D Toga, AW Optical imaging of bilingual cortical representations. Case report.. Journal of neurosurgery. . 2000; 93(4): 676-81.

Bookheimer, SY Strojwas, MH Cohen, MS Saunders, AM Pericak-Vance, MA Mazziotta, JC Small, GW Patterns of brain activation in people at risk for Alzheimer's disease.. The New England journal of medicine. . 2000; 343(7): 450-6.

Zeineh, MM Engel, SA Bookheimer, SY Application of cortical unfolding techniques to functional MRI of the human hippocampal region.. NeuroImage. . 2000; 11(6 Pt 1): 668-83.

Small, GW Ercoli, LM Silverman, DH Huang, SC Komo, S Bookheimer, SY Lavretsky, H Miller, K Siddarth, P Rasgon, NL Mazziotta, JC Saxena, S Wu, HM Mega, MS Cummings, JL Saunders, AM Pericak-Vance, MA Roses, AD Barrio, JR Phelps, ME Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America. . 2000; 97(11): 6037-42.

Dapretto, M Bookheimer, SY Form and content: dissociating syntax and semantics in sentence comprehension.. Neuron. . 1999; 24(2): 427-32.

Small, GW Chen, ST Komo, S Ercoli, L Bookheimer, S Miller, K Lavretsky, H Saxena, S Kaplan, A Dorsey, D Scott, WK Saunders, AM Haines, JL Roses, AD Pericak-Vance, MA Memory self-appraisal in middle-aged and older adults with the apolipoprotein E-4 allele.. The American journal of psychiatry. . 1999; 156(7): 1035-8.

Theodore, WH Bhatia, S Hatta, J Fazilat, S DeCarli, C Bookheimer, SY Gaillard, WD Hippocampal atrophy, epilepsy duration, and febrile seizures in patients with partial seizures.. Neurology. . 1999; 52(1): 132-6.

Bookheimer, SY Zeffiro, TA Blaxton, T Malow, BA Gaillard, WD Sato, S Kufta, C Fedio, P Theodore, WH A direct comparison of PET activation and electrocortical stimulation mapping for language localization.. Neurology. . 1997; 48(4): 1056-65.

Hertz-Pannier, L Gaillard, WD Mott, SH Cuenod, CA Bookheimer, SY Weinstein, S Conry, J Papero, PH Schiff, SJ Le Bihan, D Theodore, WH Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study.. Neurology. . 1997; 48(4): 1003-12.

Savic, I Bookheimer, SY Fried, I Engel, J Olfactory bedside test. A simple approach to identify temporo-orbitofrontal dysfunction.. Archives of neurology. . 1997; 54(2): 162-8.

Malow, BA Blaxton, TA Sato, S Bookheimer, SY Kufta, CV Figlozzi, CM Theodore, WH Cortical stimulation elicits regional distinctions in auditory and visual naming.. Epilepsia. . 1996; 37(3): 245-52.

Cuenod, CA Bookheimer, SY Hertz-Pannier, L Zeffiro, TA Theodore, WH Le Bihan, D Functional MRI during word generation, using conventional equipment: a potential tool for language localization in the clinical environment.. Neurology. . 1995; 45(10): 1821-7.

Gaillard, WD Bhatia, S Bookheimer, SY Fazilat, S Sato, S Theodore, WH FDG-PET and volumetric MRI in the evaluation of patients with partial epilepsy.. Neurology. . 1995; 45(1): 123-6.

Bhatia, S Bookheimer, SY Gaillard, WD Theodore, WH Measurement of whole temporal lobe and hippocampus for MR volumetry: normative data.. Neurology. . 1993; 43(10): 2006-10.

Blaxton, TA Bookheimer, SY Retrieval inhibition in anomia.. Brain and language. . 1993; 44(2): 221-37.